Veterynarna biotehnologija – Veterinary biotechnology, 2018, 32, 515-521 [in Ukrainian]. https://doi.org/10.31073/vet_biotech32(2)-62
Ternopil Experimental Station of the Institute of Veterinary Medicine of NAAS
DISINTOXICATION OF THE COWS ORGANISM IN POSPARTUM PERIOD
Introduction. In the postpartum period, the use of organism-hepatoprotectors, which increase the resistance of the liver to the influence of pathological factors, restore its functions with various injuries and, also, affect the reproductive system. For the detoxification of cows organism in the postnatal period, the prevention of development of postnatal diseases and the restoration of reproductive function we used the preparation Hepavex 200.
The goal of the work. To develop a scheme of detoxification of cows organism in the postpartum period the preparation Hepavex 200.
Materials and methods. Experiment was conducted in LLC “Agroprodservice invest” of Ternopil oblast in dairy cattle of Ukrainian black and white breed. Biochemical studies conducted in the laboratory of veterinary obstetrics and sanitation of Ternopil Research Station of the Institute of Veterinary Medicine of the NAAS. The cows of the experimental group (n = 10) used Hepavex 200 per os for the 1–5th day after delivery in a dose of 10.0 ml per animal for 5 days. Control was provided by cows (n = 10), which did not use preparation. Research of cow’s blood for on the content of middle mass molecules, and sialic acid before and after application of Hepavex 200.
Results of research and discussion. As a result of the research it was determined that the preparation Hepavex 200 reduces the content of sialic acids in serum by 34,31% (p≤0.01), molecules of average mass ratio coefficient to 280/254 compared to the first day of observation. In the postnatal period Hepavex 200 promotes elimination of toxic metabolites, normalizes indicators of body resistance, adjusts the amino acid balance by reducing the high concentrations of aromatic amino acids, thus prevents the development of cow’s obstetric pathology in the postnatal period. Hepavex 200 medicine usage in proposed dose during early postnatal period prevented development of postpartum pathology, service period duration reduced by 72 days (р≤0,01), insemination index by 0,4 unit, compared with relevant indicators of cows in control group.
Conclusions and prospects for further research. The preparation Hepavex 200 in the postnatal period reduces the content of sialic acids in the blood serum by 34.31% (p≤0.01), decreases the ratio of MSM280/254 by 15.15% (p≤0.05) compared to the onset beginning of the experiment, which prevents the development of pathologies of the postnatal period and reduces the duration of the service period by 46.0 ± 2.0 days, and the index of insemination by 1.8. For detoxification of the cow’s organism in the postnatal period, it is recommended to use cows the preparation “Hepavex 200” in a dose of 10.0 ml per animal for 5 days for on 1–5 days after calving. The prospect of further research is to study the influence of the Hepavix 200 on the state of the antioxidant system of the cow’s organism and the course of lipid peroxidation.
Keywords: cows, postpartum period, Hepavex 200, sialic acids, middle mass molecules, service period.