Bulletin "Veterinary biotechnology"

Veterynarna biotehnologija – Veterinary biotechnology, 2016, 28, 149-158 [in Ukrainian].

MAZUR M.V., e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., POLUPAN I.М., e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Institute of Veterinary Medicineof NAAS

GENETIC DIVERSITY OF RABIES VIRUS AND OTHER LYSSAVIRUS OF ANIMALS

Introduction. Rabies infection is characterized by lesion of central nervous system (signs of encephalomyelitis). Each year over 60,000 people and more than 1 million animals die worldwide, and more than 20 million people about 40% of which are children under 15 years receive rabies vaccination after bites. WHO Expert Committee on Rabies in its recommendations emphasizes the need to conduct typing of street isolates rabies virus based on virological and molecular genetic techniques.

The goal of the work. To analyze statistics and literature data, to study the diversity of Lyssaviruses genotypes circulating in the wildlife.

Materials and methods. For the studies, we used scientific papers, monographs, abstracts of dissertations, electronic internet resources.

Results of research and discussion.Bats are reservoirs and vectors for six of the seven classified genotypes. For five genotypes (LBV, DUVV, EBLV type 1, ABLV type 2, ABLV) bats are the only vectors. Only MOKV was not isolated from bats. Not classified genotypes of rabies virus and rabies-like Lyssaviruses also isolated from bats in various continents. Every year in the European countries it is recorded a hundred cases of rabies in bats. It was registered 5 cases of rabies in humans after being bitten by bats including three on the southeast of Ukraine and adjacent territory of the Russian Federation. In Ukraine from 2000 to 2015 it was laboratory confirmed 16 cases of rabies-like infection in bats but all the causative agents have never been identified.

Conclusions and prospects for further research:

  1. Lyssavirus is found in bat populations throughout the world.
  2. A wide range of antigenic and genetic Lissaviruses requires improvement and development of highly immunogenic vaccines against circulating genotypes.
  3. In Ukraine in 1977, 1985, and 2002 there were recorded three cases of hydrophobia in humans after unprovoked attack of bats and only in one case the virus was identified as EBLV-1.
  4. The perspective is the study of selected viral isolates, identification and typing through sequencing and phylogenetic analysis, and then comparing the results with already known genotypes of rabies virus circulating in the wild.

Keywords: rabies, bats, genotypes, lyssavirus.

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