Veterynarna biotehnologija – Veterinary biotechnology, 2016, 28, 198-207 [in Ukrainian].
National University of Life and Environmental Sciences of Ukraine
Institute of Veterinary Medicineof NAAS
DIAGNOSTICAL ASPETCTS OF CANINE ACUTE PANCREATITIS. RETROSPECTIVE RESEARCH
Introduction. The article is devoted the analysis of basic diagnostic aspects of canine acute pancreatitis. The present state of decision of questions of diagnostics, prognostication and monitoring of this pathology is reflected. Integral estimation laboratory clinical information and it is allowed to set effectiveness of criteria not only form of disease but also to define his prognosis and set a testimony to surgical treatment.
The goal of the work. To form an idea about basic diagnostic aspects of canine acute pancreatitis.
Materials and methods of research. Researches conducted by a studying analysis of foreign literary sources about to diagnostics of canine acute pancreatitis.
Results of research and discussion. Current methods of laboratory diagnosis of acute pancreatitis have a substantial value and conducted in following directions: determination of serum pancreatic enzyme levels activity determination of pancreatic enzymes (α-аmylase, lipase, trypsinum) and in urine (amylase). Activating of pancreatic enzymes at acute pancreatitis in the focus of defeat and violation of outflow on the system of deferent channels assist their entering blood and lymph ("phenomenon of deviation"). Determination of character and expressed of pancreatic destruction (level of methemalbumin, elastase, transamidinase, procalcitonine, expressed of hypoalbuminemia and hypocalcemia), an estimation of activity of the system of proteolysis inhibitions in blood (α1-antitrypsin, α2-macroglobulin, trypsin activation peptide). Estimation of intensity of inflammatory process (level of leukocytosis and neutrophilic change, sedimentation rate, interleukin-6 and 10, C - reactive protein, fibrinogenum).
Determination of level of endogenous intoxication – leukocyte index of intoxication, level of molecules of middle mass in blood. Ultrasonic research is considered the method of the first choice, taking into account a research uninvasion.
Laparoscopy is a littleinvasion, simple and popular curatively-diagnostic method. For the reliable laparoscopy diagnosis of acute pancreatitis necessary presence, at least, three any signs of disease, in different combinations.
The making progress forms of pankreanecrosis it follows obligatory research of sick dogs with to count sciagraphy of thorax. This research allows to carry out early diagnostics not only pleuropulmonary but also abdominal complications.
Conclusions and prospects for further research. However, the certain aspects of diagnostics and therapy need subsequent, high-quality planned, randomized researches of this subject. Dogs have an evolution of looks to etiology and pathogeny of acute pancreatitis, it was allowed not only to get development of modern technologies and methods of visual diagnostics picture of character of disease but also preliminary to define tactic of treatment.
The high level of lethality of dogs at the complicated acute pancreatitis induces the veterinary doctors of the whole world to the search of the most optimum going near timely diagnostics and treatment of patients with this pathology of zoons. The clinical displays of acute pancreatitis depend on many factors – form and period of disease, degree of intoxication, presence and character of complications and concomitant diseases.
Keywords: dogs, pancreatitis, pankreanecrosis, enzymes.