Bulletin "Veterinary biotechnology"

Veterynarna biotehnologija – Veterinary biotechnology, 2016, 28, 300-305 [in Ukrainian].

SHUMANSKIY YU. I., e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., OCHRYM S.A., e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Ternopil Experimental Station of the Institute of Veterinary Medicine of NAAS


Introduction. Reproduction of cattle is the basis for the development of dairy industry in Ukraine. A significant impact on the reproductive ability of cows have processes of uterine involution in postpartum period that depend on the rate of recovery of full sexual cycles and fertilization. Calving and intensification of lactation processes contribute to the functional strength of various body systems of cows that cause many metabolic diseases.

The goal of the work was to determine the effect of the preparation “Gepaveks-200” applied after calving for recovery of cows’ reproductive function and organism condition.

Materials and methods. At thefarm “Agroprodservice Invest” in Kozova Raion of Ternopil oblast we selected clinically healthy cows in the period after calving to which preparation “Gepaveks-200” was applied per os in 1-5th day at 10.0 ml dose per animal during 5 days. Ten cows which preparation did not apply were control. At the beginning and after the end of the study period we took blood for biochemical research from the control and research groups of cows.

The results of the research and discussion. The level of circulating immune complexes (CIC) in blood serum of cows after application of the preparation “Gepaveks-200” reduced by 23.68% (p≤0.01) compared to the beginning of the experiment in the blood serum of cows in the control group.

The content of immunoglobulin A in cows serum after application of the preparation “Gepaveks-200” increased by 64.29% (p≤0.001), immunoglobulin M decreased by 74.55% (p≤0.001), immunoglobulin G decreased by 44.73% (pr≤0.01) compared to the beginning of the study period. Application of the preparation to the cows reduced the content of sialic acids in serum by 34.31% (p≤0.01), and the ratio of AWM 280/254 by 15.15% (p≤0.05) compared to the beginning of the experiment, while these indicators in blood serum of cows in the control group changed significantly.

Application of the preparation “Gepaveks-200” in the recommended dose in cows in the early after calving contributed to prevention of pathology during postpartum period, duration of service period decreased by 72 days (p≤0.01), insemination index decreased by 0.4 units, compared with those of the control group in which one case of postpartum pathology and two cases of subclinical mastitis were diagnosed

Conclusions and perspectives for further research:

  1. Application of the preparation “Gepaveks-200” in the postpartum period promotes elimination of toxic metabolites, normalizes indicators of specific humoral immunity, and adjusts the amino acid balance.
  2. Preparation “Gepaveks-200” applied in recommended dose in the early postpartum period, contributes prevention of pathology during postpartum period, reduces the length of service period of 72 days (p≤0.01), decreases nsemination index by 0.4 units, compared to corresponding indices in cows of the control group.

Keywords: cows, preparation “Gepaveks-200”, detoxification, postpartum period, reproductive function.


  1. Derkach, AA, & Shepeleva, I.A. & Melnikova, N.M. (2011). Biokhimichna kharakterystyka krovi kroliv pry otruyenni kadmiyem ta vvedenni preparatu hepaveks 200. [Biochemical characterization of rabbit blood poisoning with cadmium and drug administration hepaveks 200]. Naukovo-tekhnichnyy byuleten' Instytutut biolohiyi tvaryn DNDKI vetpreparativ ta kormovykh dobavok – Scientific and technical bulletin Institute of animal biology GNIKI Veterinary medicines and feed additives, Vol. 12, 1 (2), 21-25 [in Ukrainian].
  2. Strel'nykov, S.A., Meshcheryakov, S.V., & Merzlenko, R.A. (2007). Toksykolohycheskaya kharakterystyka novoho hepatotropnoho preparata hepatoveks [Toksykolohycheskaya characteristics of the new hepatotropic drug hepatoveks]. Zbirnyk naukovykh prats' KhDZVA – Scientificresearchjournalof KSZVA, Vol. 14 (39), 2 (2), 229-231 [in Ukrainian].
  3. Kazyev, Zh.Y, Zamanbekov, N.A, & Baynyyazov, A.A. (2011). Korrektsyya ymmunoheneza pry ostrom toksycheskom hepatyte preparatom Gepaveks-200 [Correction of immunogenesis at acute toxic hepatitis with preparation hepato-200]. Proceedings of The Scientific research in the field of veterinary medicine and their results: Konferencija posvyashchennaia 20-letyyu nezavysymosty KazakhstanaConference dedicated to 20th anniversary of Kazakhstan's independence, Vol. LVII, (pp. 171-174). Kazakhstan: KazNIVI [in Russian].
  4. Kondrakhin, I.P., & Arkhipov, A.V., & Levchenko, V.J., & Talanov, G.A., & Frolova, L.A., & Novikov, V.E. (2004). Metody veterinarnoj klinicheskoj laboratornoj diagnostiki [Methodsofveterinaryclinicallaboratorydiagnostics]. Moscow: Kolos [in Russian].
  5. Vlizlo, V.V., Fedoruk, R.S., & Ratych, I.B. (2012). Laboratorni metody doslidzhen' u biolohiyi, tvarynnytstvi ta veterynarniy medytsyni: dovidnyk [Laboratory methods of research in biology, veterinary medicine: a guide]. Lviv: SPOLOM [in Ukrainian].
  6. Gabrielyan, N.I., & Lipatov, V.I. (1984). Opredelenye soderzhanyya srednemolekulyarnikh peptydov v krovy [Determination of the content in the blood middle molecular peptides]. Laboratornoe delo – Laboratory business, 3, 138-140 [in Russian].
  7. Lakyn, G.F. (1990). Byometryya: Uchebnoe posobye dlya byolohycheskykh spetsyal'nostey vuzov [Biometrics: A manual for biological specialties universities]. Moscow: Higher School [in Russian].

Download full text in PDF