Bulletin "Veterinary biotechnology"

Veterynarna biotehnologija – Veterinary biotechnology, 2018, 32(1), 139-146 [in Russian]. https://doi.org/10.31073/vet_biotech32(1)-18

KUCHINSKY M.P., e–mail: This email address is being protected from spambots. You need JavaScript enabled to view it., SONOV A.A., e–mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

S.N. Vyshelesky Institute of Experimental Veterinary Medicine, Minsk, Republic of Belarus

THE STUDY OF THE SAFETY OF A NEW INJECTABLE VETERINARY DRUG ON THE BASIS OF MACROELEMENTS

Introduction. The article presents results of studying of various methods of parenteral injection of the experimental sample of a new veterinary drug on laboratory animals intended for riddance of deficiency of calcium, phosphorus and magnesium, and also for hypomacroelementosis' prevention.

The goal of the work was to study the methods of injection the experimental sample of a new veterinary drug and its laboratory animals' evaluation.

Materials and methods. The drug was injected subcutaneously, intramuscularly and intravenously to rabbits, living weight 2.5–3.0 kg. The tissue biopsy with histological examination from the injection sites was also performed after intramuscular injection. The experiment was delivered to explore the drug pyrogenicity after intravenous route injection.

Results of research and discussion. Changes were no observed in the clinical status of the animals, the animals readily took food and drank water, and there were no pathological reactions at the site of the skin after experimental sample was injected subcutaneously. Lameness was observed, at the injection site edema, soreness after intramuscular injection. Histological examination revealed the presence, at the injection site of the experimental sample of the preparation, necrosis of muscle tissue, a violation of the structure of the muscle fibers. The intravenous injection is safe because it does not cause deterioration in the clinical state of laboratory animals, does not cause hyperthermia, thrombophlebitis at the site of administration of the drug.

Conclusions and prospects for further research. From the data obtained in the experiments follows the experimental sample of the new veterinary drug is safe after subcutaneous and intravenous injection, since it does not cause deterioration of the clinical state, nor does it cause pathological reactions in the organs and tissues of the organism of laboratory animals.

Keywords: cattle breeding, veterinary drug, rabbits, pyrogenicity, macro elements.

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