Bulletin "Veterinary biotechnology"

Veterynarna biotehnologija – Veterinary biotechnology, 2018, 32(1), 416-424 [in Ukrainian]. https://doi.org/10.31073/vet_biotech32(1)-55

POLISCHCUK I., e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., PINCHUK N.e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

State Scientific Control Institute of Biotechnology and strains (DNKIBSHM)


The aim of this study is to analyze role of animal vaccination against listeriosis in the wealtness of agricultural animal and reducing human infection trough animal product. The paper is devoted to the problem of vaccination against listeriosis in Ukraine and in the world. Nowadays listeriosis is one of the most important food-borne diseases of humans. Although the frequency of listeriosis is relatively low, the mortality of the systemic/encephalitic disease can be very high, with values in the vicinity of 20–30%.

Results. At the beginning of the paper brief description of bacterium that causes Listeriosis is given. A number of molecular and cellular determinants of virulence have been identified for this intracellular pathogen. Much attention is given to the mechanism of immune response development. Both the innate and adaptive immune systems are crucial to the recognition and elimination of this pathogen from the host. Innate immune responses are essential for early control of L. monocytogenes infection. Due to the intracellular niche of the bacteria, CD4 and CD8 T cells comprise most of the adaptive immune response. It is noted that there are three strategy of listeriosis vaccines construction – using live attenuated vaccine, killed bacteria and modern types of vaccines like DNK vaccines, nanovaccines. It has proven very difficult to develop effective vaccines against L. monocytogenes which, as an intracellular organism, requires effector T cells for an effective immune response.

Conclusion. Devolopment of vaccine for animals is actual and open question. Deep economical investigation should be done to find out which type of vaccine against listeriosis is the most effective.

Keywords: vaccination, listeriosis, L. Monocytogenes, сell-mediated immunity


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