Bulletin "Veterinary biotechnology"

Veterynarna biotehnologija – Veterinary biotechnology, 2018, 32(1), 459-465 [in Ukrainian]. https://doi.org/10.31073/vet_biotech32(1)-62

ZADOROZHNA V.e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.VYNNYK N., e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

SI "The L.V. Gromoshevsky institute of epidemiology and infectious disease of NAMS of Ukraine"

QUESTIONS OF BIOETHICS AND BIOSAFETY IN THE PROBLEM OF BIOTECHNOLOGY AND USE OF VACCINE FOR PREVENTION OF HUMAN INFECTIOUS DISEASES

Introduction. The constant search and expansion of the spectrum of infectious diseases against which vaccines are created, the development of innovative technologies for vaccine procurement, the widespread use of immunization among healthy individuals, in particular as obligatory vaccinations, direct or indirect impact of massive immunization measures on the country's biosafety and other needs to be addressed by a number of bioethical and biosecurity problems.

The purpose of the work is to analyze some issues of bioethics and biosecurity related to the production and use of vaccines for the prevention of human infectious diseases.

Materials and methods of research. The article identified and analyzed the main issues of bioethics and biosecurity associated with the production and use of vaccines for the prevention of human infectious diseases. The issues of bioethics and biosecurity related to the use of unlicensed vaccines in emergency epidemic conditions (on the example of the epidemic of Ebola disease) are discussed; with the need to improve the technology of obtaining seasonal and pandemic influenza vaccines (the use of transplant cell cultures and other technologies instead of chicken embryos, especially concerning the virus A (H3N2)), strengthening measures to prevent unpredictable events after vaccination, etc. Emphasizes the role of vaccination as one of the most significant medical achievements of mankind.

Conclusions and perspectives off other research. In the problem of vaccination, it is always necessary to take into account the fact that the vaccine is administered in a healthy way, and unlike the therapeutic drug, it does not allow us to trace the dynamics of health improvement. At the level of an ordinary member of society, it often complicates awareness of the benefit / risk ratio of vaccination. Vaccine prevention as an object should combine simultaneously the medical, bioethical principles and principles of biosafety, aimed at both society in general and each individual. Its widespread use requires constant, serious scientific support and high moral, social and economic responsibility at all levels – from scientific research, implementation to production, health care to the implementation of immune prevention programs at the state level.

Keywords: vaccine prophylaxis, bioethics, biosecurity, technological process, infectious diseases.

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