Bulletin "Veterinary biotechnology"

Veterynarna biotehnologija – Veterinary biotechnology, 2020, 36, 155-165 [in Ukrainian]. https://doi.org/10.31073/vet_biotech36-16

SIRYK O.O.1,2, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., TSYGANOVYCH O.A.2,3, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., PROKOPENKO V.A.2,3, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., ZHOVNIR О.M.1, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., TІUTІUN S.M.1, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

1Institute of Veterinary Medicine NAAS

2F.D. Ovcharenko Institute of Biocolloidal Chemistry NAS Ukraine

3National Technical University of Ukraine "Igor Sikorsky Kyiv Polytechnic Institute"

NANOSIZED SELENIUM PARTICLES – PERSPECTIVE THERAPEUTIC AGENT WITH A WIDE SPECTRUM OF ACTION FOR VETERINARY NEEDS (review)

Introduction. Special attention in veterinary medicine is given to the application of different nanomaterials due to their size, shape and unique physicochemical properties. However, current studies on the properties of nanoscale selenium particles are not sufficiently covered.

The goal of the work was analysis of scientific literature on the identification of selenium nanoparticles properties and determination of main directions of their most effective use in veterinary medicine.

Materials and methods. The research was conducted by studying and analyzing literary sources devoted to the production, properties and application of nanoscale selenium particles.

Results of research and discussion. The mechanisms of enhancing bioavailability and antioxidant activity while reducing the detrimental effect of SeNP on cells compared to its inorganic and organic forms are shown. Particular attention is paid to the study of the toxic effects of various forms of selenium on the living organism, it was shown that nanosized selenium has several advantages, but there is a narrow boundary between the safety area and the potential toxic effects of selenium, which is of great importance in the creation of bioadditives and drugs. However, its properties should be thoroughly investigated using methodological principles and baseline evaluations of medicinal nanoparticles, since, like other nanomaterials, it is size- and form-dependent. It is found that for obtaining SeNP with the given parameters it is very important to choose the method of their synthesis and to determine the precursors – surfactants and biocompatible compounds for the stabilization of lyophobic colloidal suspensions of nanoparticles. The effectiveness of therapeutic use of SeNP in veterinary medicine is shown to improve the immune, reproductive, hepatobiliary functions in animals, and in the fight against cancer.

Conclusions and prospects for further research. SeNP are promising for use as nutritional supplements, state-of-the-art antioxidant and anti-inflammatory drugs, for the creation of systems for the repair of biological tissues and targeted drug delivery, as well as for new diagnostic approaches and systems for early diagnosis of diseases. The further development of nanobiotechnology in this direction is the development of new alternative methods of obtaining such particles, as well as the improvement of existing protocols for their synthesis and stabilization, creating on the basis of SeNP bioconjugates with specified target properties.

Keywords: nanoscale selenium particles, biological activity, toxic effect, drug nanopreparations.

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