Bulletin "Veterinary biotechnology"

Veterynarna biotehnologija – Veterinary biotechnology, 2021, 39, 75-87 [in Ukrainian]. https://doi.org/10.31073/vet_biotech39-07

MEZHENSKYI A.O., e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Institute of Veterinary Medicine NAAS


Introduction. The most common ophthalmic diseases in horses is uveitis, which is registered in all countries of the world and affects horses of all breeds, ages and genders and is the most common cause of vision loss. Leptospirosis is a common cause of uveitis in horses in Europe, so the development of new tools and methods for treatment of this pathology is relevant.

The goal of the work was to develop pathogenetically based protocols for the treatment of leptospirosis uveitis of horses and analyze their effectiveness.

Materials and methods. The diagnosis of uveitis was made comprehensively according to the case history, clinical and ophthalmological examination of horses.

Blood serum was taken from horses with acute uveitis and examined by the microagglutination test for leptospirosis. Horses with leptospiral uveitis were treated according to the standard and developed protocols. The effectiveness of treatment was determined according to the clinical and ophthalmological criteria developed by us.

Results of research and discussion. The efficiency of horse treatment with pharmacine and atropine sulfate (standard protocol) was 50.0-67.7%, and after adding amizone (improved protocol) – 80.0-85.7%, depending on the form of uveitis.

Introduction of novocaine and prednisolone into the tenon capsule, together with an improved treatment protocol, allows increasing the therapeutic effect by 1.75-1.8 times compared to subconjunctival administration.

The inclusion of anfluron in the new developed protocol for the treatment of horses in acute leptospiral uveitis provided a reduction of treatment duration by 10 days.

Conclusions and prospects for further research. The inclusion of amizone in the treatment protocol for leptospiral uveitis in horses increases the efficiency by 15.6-30%. Adding to an improved treatment protocol the introduction of the solution of novocaine and prednisolone into the tenon capsule of the eye increases its effectiveness.

Application of anfluron in the protocol of complex treatment of horses in acute leptospiral uveitis can significantly increase its effectiveness, reduce duration of the treatment by 10 days, as well as the number and severity of complications.

Prospects for further research include the development and study of the therapeutic effectiveness of complex treatment schemes for horses in chronic (recurrent) leptospiral and idiopathic uveitis.

Keywords: horses, leptospirosis uveitis, complex treatment.


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