Veterynarna biotehnologija – Veterinary biotechnology, 2022, 40, 98-109 [in Ukrainian]. https://doi.org/10.31073/vet_biotech40-09
Institute of Veterinary Medicine NAAS
COMPARISON OF DIFFERENT SCHEMES OF PREMEDICATION OF DOGS BEFORE GENERAL INTRAVENOUS ANESTHESIA
Introduction. Premedication is the pharmacological preparation of the body for general anesthesia. The list of drugs for premedication of animals in Ukraine is constantly growing, but studies on the study of their effect on the body of dogs as part of premedication mixtures have not been conducted recently.
The goal of the work. To study the sedative-tranquilizing properties of premedication mixtures of different composition and to determine the best option for dogs before general intravenous anesthesia.
Materials and methods. The work was performed in a veterinary clinic on dogs of different breeds and gender, aged 1–5 years, weighing 10–20 kg, divided into three groups (n=5). Atropini sulfate, Dimedrol and Butorphanol were administered to animals for the premedication, in addition Acepromazine maleate to the dogs of the first group, Xylazine hydrochloride – to the second, Medetomidine hydrochloride – to the third one. To determine the body’s response to the effect of premedication mixtures, the cardiovascular, respiratory and nervous systems were monitored, the duration of premedication stages (beginning, development, weakening, end) was recorded, and the degree of sedative-tranquilizing effect of premedication was determined.
Results of research and discussion. Premedication mixtures that were administered to dogs of the second and third groups, which included Xylazine hydrochloride and Medetomidine hydrochloride, respectively, had the most pronounced sedative-tranquilizing effect, while the degree of sedative-tranquilizing effect was moderate in dogs treated with Acepromazine maleate. Comparison of premedication mixtures of different composition indicates that all of them can be successfully used for premedication of dogs before general intravenous anesthesia.
The choice of a combination of premedication mixtures should depend on the features that the anesthetist must take into account before conducting general intravenous anesthesia: the desired speed and degree of sedative-tranquilizing effect of premedication mixtures, the duration of general intravenous anesthesia, the condition of the animal before anesthesia.
Conclusions and prospects for further research. A premedication mixture containing Acepromazine maleate in its composition causes hypothermia, but it has insignificant effect on the cardiovascular and respiratory systems of the body, compared with premedication mixtures containing Xylazine hydrochloride or Medetomidine hydrochloride.
Prospects for further research are to study the cost-effectiveness of premedication mixtures of different composition before general intravenous anesthesia in dogs, as well as the effect of premedication mixtures directly on the effectiveness of general intravenous anesthesia.
Keywords: dogs, premedication, premedication mixture, general intravenous anesthesia, sedative-tranquilizing effect.