Bulletin "Veterinary biotechnology"

Veterynarna biotehnologija – Veterinary biotechnology, 2022, 40, 98-109 [in Ukrainian]. https://doi.org/10.31073/vet_biotech40-09

MEZHENSKYI A.O., e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Institute of Veterinary Medicine NAAS


Introduction. Premedication is the pharmacological preparation of the body for general anesthesia. The list of drugs for premedication of animals in Ukraine is constantly growing, but studies on the study of their effect on the body of dogs as part of premedication mixtures have not been conducted recently.

The goal of the work. To study the sedative-tranquilizing properties of premedication mixtures of different composition and to determine the best option for dogs before general intravenous anesthesia.

Materials and methods. The work was performed in a veterinary clinic on dogs of different breeds and gender, aged 1–5 years, weighing 10–20 kg, divided into three groups (n=5). Atropini sulfate, Dimedrol and Butorphanol were administered to animals for the premedication, in addition Acepromazine maleate to the dogs of the first group, Xylazine hydrochloride – to the second, Medetomidine hydrochloride – to the third one. To determine the body’s response to the effect of premedication mixtures, the cardiovascular, respiratory and nervous systems were monitored, the duration of premedication stages (beginning, development, weakening, end) was recorded, and the degree of sedative-tranquilizing effect of premedication was determined.

Results of research and discussion. Premedication mixtures that were administered to dogs of the second and third groups, which included Xylazine hydrochloride and Medetomidine hydrochloride, respectively, had the most pronounced sedative-tranquilizing effect, while the degree of sedative-tranquilizing effect was moderate in dogs treated with Acepromazine maleate. Comparison of premedication mixtures of different composition indicates that all of them can be successfully used for premedication of dogs before general intravenous anesthesia.

The choice of a combination of premedication mixtures should depend on the features that the anesthetist must take into account before conducting general intravenous anesthesia: the desired speed and degree of sedative-tranquilizing effect of premedication mixtures, the duration of general intravenous anesthesia, the condition of the animal before anesthesia.

Conclusions and prospects for further research. A premedication mixture containing Acepromazine maleate in its composition causes hypothermia, but it has insignificant effect on the cardiovascular and respiratory systems of the body, compared with premedication mixtures containing Xylazine hydrochloride or Medetomidine hydrochloride.

Prospects for further research are to study the cost-effectiveness of premedication mixtures of different composition before general intravenous anesthesia in dogs, as well as the effect of premedication mixtures directly on the effectiveness of general intravenous anesthesia.

Keywords: dogs, premedication, premedication mixture, general intravenous anesthesia, sedative-tranquilizing effect.


  1. Chepkyj, L.P., Glumcher, F.S., Novitska-Usenko, L.V., et al. (2000). Anesteziologija ta intensyvna terapija: Pidruchnyk [Anesthesiology and Intensive Care: Textbook]. Kyiv: Vyshha shkola [in Ukrainian].
  2. Vlasenko, V.M., & Tyhonjuk, L.A. (2000). Veterynarna anesteziologija [Veterinary anesthesiology]. Bila Cerkva [in Ukrainian].
  3. Dugdale, A. (Ed.). (2020) Veterinary Anaesthesia: Principles to Practice. (2th ed.). Wiley-Blackwell.
  4. Pulniashenko, P.R. (2000). Anesteziologija i reanimatologija sobak i koshek [Anesthesiology and resuscitation of dogs and cats]. Akvarjum LTD [in Russian].
  5. Seymour, C., & Gleed, R. (1999). Manual of small animal anaesthesia and analgesia. (7th ed.). British Small Animal Veterinary Association.
  6. Polatajko, O.R. (2009). Veterinarnaja anestezija: prakt. posobie [Veterinaryanesthesia: pract. manual]. Kyiv: «VD «Periskop» [in Ukrainian].
  7. Rublenko, S.V. (2010). Kliniko-eksperymentalne obgruntuvannja suchasnogo anesteziologichnogo zabezpechennja tvaryn zalezhno vid typu boliovoii reakcii [Clinical and experimental substantiation of modern anesthesiological support of animals depending on the type of pain response]. Doctor’s thesis. Bila Tserkva [in Ukrainian].
  8. Mezhenskyj, A.O., Petrenko, O.F., & Melnychuk, S.D. (2007). Premedykacija ta ocinka ii efektyvnosti u veterynarnij anesteziologii [Premedication and evaluation of its effectiveness in veterinary anesthesiology]. Vet. medycyna UkrainyUkrainian veterinary medicine, Vol. 7, 30-34 [in Ukrainian].
  9. Mezhenskij, A.A. (2009). Monitoring anesteziologicheskogo obespechenija zhivotnyh v veterinarnoj hirurgii [Monitoring of anesthetic management of animals in veterinary surgery]. VeterinarijaVeterinary medicine, Vol. 7, 43-47 [in Russian].
  10. Mezhenskij, A.A., & Petrenko, O.F. (2010). Opredelenie operacionno-anesteziologicheskogo riska v veterinarnoj hirurgii [Determination of operational and anesthetic risk in veterinary surgery]. VeterinarijaVeterinary medicine, Vol. 2, 52-54 [in Russian].
  11. Mezhenskyj, A.O., Petrenko, O.F., & Melnychuk, S.D. (2010). Pat. na korysnu model №50636 Ukraina. Sposib vyznachennja efektyvnosti premedykacii u veterynarnij anesteziologii [Method of determining efficiency of premedication in veterinary anesthesiology]. sis.ukrpatent.org. Retrieved from https://sis.ukrpatent.org/uk/search/detail/259069/.
  12. Mezhenskyj, A.O., Melnychuk, S.D., & Petrenko, O.F. (2009). Pat. na vynahid №85228 Ukraina. Sposib vyznachennja anesteziologichnogo ryzyku u veterynarnij hirurgii [Method of determining anesthesia risk in veterinary surgery]. sis.ukrpatent.org. Retrieved from https://sis.ukrpatent.org/uk/search/detail/418149/.

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