Bulletin "Veterinary biotechnology"

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Veterynarna biotekhnolohiia – Veterinary biotechnology, 2022, 41, 100-107 [in Ukrainian]. https://doi.org/10.31073/vet_biotech41-10

KOSHEVOY V.I., e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.,

NAUMENKO S.V., Dr. Sci. (Vet. Med.), Prof., e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

State Biotechnological University

 

 DYNAMICS OF PEROXIDATION PROCESSES IN MALE RABBITS UNDER EXPERIMENTAL LPS-INDUCED OXIDATIVE STRESS

 The article presents the results of an experimental study on the creation of a model of male infertility due to lipopolysaccharide-induced oxidative stress. The objectives of the research were to establish the dynamics of peroxidation processes in the blood serum of male rabbits during acute and chronic intake of LPS solution as OS inducers. A significant increase in the content of DC by 1.85 times (P˂0.001), TBA-RC by 80.8% (P˂0.001) and stable metabolites of the NO cycle by 88.0% (P˂0.001) with a single administration of LPS solution was noted. An increase in the intensity of lipoperoxidation processes during chronic intake was observed as was evidenced by an increase in the content of DC by 52.1% (P˂0.001), TBA-RC by 42.5% (P˂0.001) and NOх by 42.3% (P˂0.001).

Keywords: lipopolysaccharide, prooxidant-antioxidant balance, diene conjugates, thiobarbiturate-active products, Nitric oxide cycle.

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