Bulletin "Veterinary biotechnology"

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Cite:  Koshevoy V.I., Naumenko S.V., Zhukova I.O., & Orobchenko O.L. (2024). Prospects for the use of resveratrol – a polyphenol phytoantioxidant in veterinary reproduction (review) [Perspektyvy zastosuvannia resveratrolu – polifenolnoho fitoantyoksydantu v veterynarnii reproduktolohii (ohliadova stattia)]. Veterynarna biotekhnolohiia – Veterinary biotechnology, 44, 50-58. https://doi.org/10.31073/vet_biotech44-04  [in Ukrainian].

 

KOSHEVOY V.I., e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., NAUMENKO S.V., e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., ZHUKOVA I.O., e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., OROBCHENKO O.L., e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

State Biotechnological University 

 

PROSPECTS FOR THE USE OF RESVERATROL – A POLYPHENOL PHYTOANTIOXIDANT IN VETERINARY REPRODUCTION (REVIEW)

    Introduction. One of the most studied natural non-flavonoid polyphenols from the stilbene group is resveratrol. The positive effects of resveratrol in many diseases made it possible to assert its antidiabetic and antimicrobial properties, antitumor and anti-inflammatory effects. However, there is little data on the effect of this substance on sexual function.

   The goal of the work was to summarize data on the main properties of resveratrol and its effect on the reproductive capacity of animals.

   Research materials and methods. The research used scientific articles in which the experimental results and theoretical principles of the use of resveratrol in biomedical research published in 2007-2024 from the Scopus, Pubmed and Google Scholar databases were presented.

   Research results and discussion. Exposure to metal NPs causes bioaccumulation and toxic effects in the reproductive system, which confirms the potential risk for animals and human health and the environment. NPs can pass through hematotestinal, placental, and epithelial barriers that protect reproductive tissues and then accumulate in reproductive organs. These effects are related to composition, modification, concentration, agglomeration and route of administration. Note that the impact of NPs can be multidirectional, and some of them are effectively used to neutralize the toxic effects of others.

   Conclusions and prospects for further research. Resveratrol, as a chemical compound, is characterized by structural and functional affinity with the female sex hormone estrogen, and due to its ability to bind to its receptors, it can regulate them, contributing to the maturation of oocytes, improving steroidogenesis, and positively affecting the sexual function of females. The antioxidant properties of resveratrol ensure the effectiveness of its use in cryopreservation of sperm, but the possibility of using it to improve the quality of sperm requires research. Pharmacokinetic properties of resveratrol limit its widespread use as a medicinal product – low bioavailability, poor solubility, and rate of metabolic transformation require improvement. The perspective of further research is the experimental assessment of the effect of resveratrol as a feed additive in animal diets on the state of their reproductive capacity, antioxidant potential, etc.

Keywords: antioxidants, reproduction, resveratrol, males, females.

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